|
Authors:
Feras Samir, Mahmoud Mansour, Mohammad S Shawaqfeh, Abdel kareem Albekairy, Saleh Al Dekhail, Abdul malik Alkatheri, Saudi Arabia
|
|
Abstract:
Aim of the study:
Presence of protein in urine is negatively associated with kidney function. In order to evaluate the contribution of proteinuria from native kidney to post renal transplant urine protein content, we estimated protein urea before and weekly after kidney transplantation. The relation of proteinuria and serum biochemical parameters in clouding serum creatinine, fasting blood sugar, cholesterol level and immunosuppressive drugs used is also investigated.
Methods:
Proteinuria was evaluated according to definition of >300 mg/24 hours. Patients were classified into three groups, group (A)< 300 mg/24hours. Group (B) 300-1000 mg/24hours and group (C)> 1 gm/24 hours. All Patients were treated with immune suppressive drugs; tacrolimus, my co phenol late mo fetil and prednisone. Anti-hypertensive drugs (ACEI and ARB) that might reduce protein urea were not used.
We tested the association between level of protein urea and serum creatinine, fasting blood glucose, HBA1C and Cholesterol. Moreover, we also investigated the association with hypertension, diabetes mellitus and immunosuppressive drugs used.
Results:
A total of 68 renal transplants recipients were included in our study with mean age of 40.4 years and 57.4% were male. The prevalence of proteinuria in post renal transplant patients based on the average of recorded protein urea during first eight weeks, was27.9 % compared with 98.3% in pre-transplant patients. Based on resolution of proteinuria in our study, in pre-transplant patients, group A was 1.6%, group B 25.8% while group C was 72.5%. However, in post-transplant patients, group A was 72%, group B23.5%, and group C 4.4%. Weekly assessment of protein urea for two months indicated significant amelioration in proteinuria level and a remarkable reduction in serum creatinine levels. The prevalence of protein urea during week 8 was (95.2%, 2.9%, and 1.4%) in group A, B and C, respectively. In addition, patients with non-detectable level increased to 82%. No correlation between fasting blood sugar, HBA1C, cholesterol land protein uria were observed.
Conclusion:
There was a dramatic decrease in proteinuria after renal transplantation. Moreover, a gradual decrease in renal proteinuria during first eight weeks was positively associated with remarkable melioration in kidney function.
|
