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Abstract:
Introduction:
Severe acute
respiratory syndrome virus also known as SARS CoV-2 is a novel developed RNA
virus of beta group Coronavirus, which has created a Pandemic affecting
millions of people worldwide since December 2019. The prevalence of Acute
hepatitis in Covid-19 patients on initial presentation is still indeterminate.
However, to the best of our knowledge very few Covid-19 Hepatitis cases are
reported and we have reported a case series of 10 nos. of COVID-19 confirmed
patients with anicteric Hepatitis.
Methods:
We undertook a
retrospective study of 10 Covid positive cases in the age group between 18 to
60 years admitted to our Covid Centers between 1st July to 15th Aug 2020.
Required investigations including X-ray chest and ECG of these patients were
analysed closely. Patients with pre-existing liver disease, primary biliary
cirrhosis, alcoholic hepatitis, non alcoholic fatty hepatitis and auto immune
hepatitis were excluded from the study.
Procedures:
Medical
reports from Covid Centers were collected and were used for data collection and
analysis by trained medical personnel in a sequential manner. All relevant data
was recorded and after complete analysis these patients were selected for the
present study.
Results:
Demographic profile
and epidemiological characteristics of all the patients were recorded. Clinical
features, laboratory parameters and treatment modalities of all the patients
were recorded and analysed closely.
Conclusion:
From this case
series we conclude that COVID-19 Hepatitis is not uncommon in patients infected
with SARS CoV-2 and it can be used as an assessment tool in suspected patients
to assess the confirmation rate of patients prior to confirmation with RT-PCR
in resource constraint areas as abnormal LFT is detected prior to appearance of
symptoms. As all the cases we detected were anicteric, it may be difficult to
assess clinically and early blood investigations are advised for confirmation.
We recommend further studies for the confirmation of our findings and as it is
the very first case series of COVID-19 anicteric hepatitis reported it may help
as a guiding torch for future references.
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