Title:
Adult Macrophagic Activation Syndrome: About a Case

Authors:
Fadoua ELFARSSANI, Raihane Bahri, Adil JAHDAOUI, Hicham Yahyaoui, Mustapha AITAMEUR, Mohammed CHAKOUR, Morocco

Abstract:

Macrophagic activation syndrome or lymphohistiocytic hemophagocytosis is characterized by an uncontrolled and uncontrolled stimulation of the immune system which results in the infiltration and destruction of multiple organs by cytotoxic cells and macrophages with hemophagocytosis, and systemic hyper inflammation.

Clinically, it results in fever, organomegaly, weight loss, and biologically in bi/pancytopenia, cytolysis/cholestasis, hyperferritinemia, and hemostasis disorders. The histological demonstration of the macrophage with hemophagocytosis remains the gold standard, whereas it is often absent at the very beginning, which can complicate the diagnosis. In adults, the clinical course is lymphohistiocytic hemophagocytosis mild, resolving with treatment of the etiology in question, with rapidly fatal multiorgan failure.