Title:
Migraine with Dysautonomia Related to Mitochondrial Polymorphisms and Adrenergic Alpha Receptors

Authors:
Ingrid Adriana Lopez-Chente1, Antonio Bravo-Oro, Víctor M. Saavedra-Alanísz, Carmen Esmer, Juan M. Shiguetomi-Medina, Ildefonso Rodriguez-Leyva, Mexico

Abstract:

Introduction: Migraine has a high prevalence. It is among the first five most disabling diseases worldwide, and it is the most common primary headache in the pediatric age. There are isolated studies of the association of migraine with mitochondrial polymorphism 16519C> T and dysautonomia with polymorphism Arg347Cys of the first adrenergic alpha receptor (ADRA1A). It is common in a pediatric neurology service to find patients where both problems converge in the same subject.
Objective. The purpose of the study was to evaluate a possible association between migraine with dysautonomia and mitochondrial polymorphisms and alpha-adrenergic receptors.
Subjects and methods: An observational, analytical, prospective, and cross-sectional study of 44 participants was designed, divided into four groups: dysautonomia, migraine, migraine with dysautonomia, and controls; a blood sample was taken and analyzed by PCR to determine the presence of mitochondrial polymorphism related with migraine, as well as the most frequent genotypic variant of the alpha-adrenergic receptor 1A.
Results: Both the mitochondrial polymorphism 16519C> T (p = 0.003) and the Arg / Arg phenotype of Arg347Cys ADRA1A more frequently migraine groups explained by their multifactorial etiology, with high heterozygous frequency Arg / Cys in the control group.
Conclusion: The high frequency of heterozygotes (Arg / Cys) in the control group can confer a state of normotension and migraine protection in this population.

DOI: http://dx.doi.org/10.51505/ijmshr.2021.5305