Title:
Evaluation of Serum Lipid Profile at Different Trimesters among Pregnant Women in Ovia North-east Local Government Area, Edo State, Nigeria

Authors:
Comfort Bosede Enitan, Humphrey Benedo Osadolor, Kester Awharentomah Digban, Eguagie Osareniro Osakue, James Alao, Esther Ngozi Adejumo, Oluwakemi Anike Ladipo, Ayodele, Adelakun, Chukwuani Ufuoma, Francis Awusha Ogar, Chigozie Victor Okoro, Nigeria

Abstract:

The aim of this study was to evaluate the lipid profile of pregnant women at different trimester in Ovia North-East Local Government Area, Edo State, Nigeria. A total of 200 blood specimens (150 pregnant women and 50 non-pregnant women), aged between 18-49 years, were randomly collected from consenting women. Biochemical parameters including: Total Cholesterol (TCHL), Triglycerides (TG), High density lipoprotein (HDL) and Low density lipoprotein (LDL) were analyzed using standard spectrophotometric technique. A standard Height and Weight Measurement Unit (HWMU) was used to measure the height (m) and weight (Kg) of the participants and their BMI thereafter calculated using the formula: Weight/Square Height (Kg/m2).  Data were entered into Microsoft Excel and statistical analysis was carried out using SPSS-18.0 (Statistical Package for Social Sciences - Version 18.0) Software Package. In comparison with the control, the serum levels of Triglycerides (TG), High density lipoprotein (HDL), as well as Very Low density lipoprotein (VLDL) changed significantly (P=0.00) in pregnant women with progression in pregnancy particularly in the third trimesters. While on the other hand, the serum levels of Total Cholesterol (TCHL) and the Low density lipoprotein (LDL) of the pregnant women were significantly (P=0.00) elevated in the second trimester compared to the control. TCHL (189±4.23 mg/dl), TG (166±5.12 mg/dl), HDL (78±2.59 mg/dl), VLDL (33.0±1.02 mg/dl), and BMI (24.2±0.4 Kg/m2) were significantly (P=0.00) elevated in the pregnant women than the control (142±5.34 mg/dl, 108±5.02 mg/dl, 39±3.20 mg/dl, 23.1±1.5 mg/dl, and 22.1±0.3 Kg/m2, respectively), except LDL (P=0.90). The outcome of this study shows that hyperlipidemia is highest in the third trimester of pregnancy and this period may be the most vulnerable for coronary heart disease for women who are atherosclerotic, hence the need for close monitoring of the lipid profile during this phase of pregnancy.

DOI: http://dx.doi.org/10.51505/ijmshr.2021.5513