Title:
Prognostic Effects of Short-term Blood Pressure Variability Among Patients With Heart Failure With Reduced Ejection Fraction

Authors:
Havyarimana Juvenal, Chengkun Kou, Wang Ming Ming, Yu Jing*, China

Abstract:

Objective: To assess the prognostic impact of short-term blood pressure variability among heart failure patients with reduced ejection fraction.

Methods: The pooled endpoint of cardiac death, stroke,  myocardial infarction, and hospitalization were examined in 156 HF subjects with reduced EF. All subjects had their blood pressure measured ambulatorily. Mean average real variability (ARV) 24-hour systolic BP (n=78; n=78) was used to classify individuals as having the lowest (0.77 mmHg) or the highest (0.77 mmHg) ARV.

Results:

Throughout the follow-up period (7.6 ± 3.6 months), 107 events occurred, of which 29 (19%) were cardiac deaths, 18 (12%) myocardial infarction, 9 (6%) stroke, and 51(33%) hospitalizations.  Patients with low 24-hour systolic ARV had significantly higher cardiac death and MI than those with high 24-hour systolic ARV. Risk of negative outcomes identified as an independent variable by logistic regression analysis; age (AOR 1.08, 95% CI: 1.01-1.15; p = 0.01), coronary artery disease (AOR 0.34, 95% CI: 0.12-0.98; P = 0.04), valvular cardiomyopathy (AOR 0.08, 95% CI: 0.09-0.82; P = 0.03), daytime systolic BP (AOR 1.25,95% CI:1.04-1.49; p=0.01) daytime diastolic BP (AOR 1.07, 95% CI: 1.00-1.14; p = 0.04) and 24-hour DBP (AOR 1.12, 95% CI: 1.02-1.22; P=0.01)

Conclusion:

Low ARV of 24-hour systolic BP is associated with greater cardiovascular risk indicators daytime systolic BP variability, night-time systolic BP variability, 24-h systolic BP variability, and 24-h diastolic BP variability with HF with reduced EF patients.

DOI: http://dx.doi.org/10.51505/ijmshr.2022.6109