Title:
Modification of Immune Markers in Patients With Novel Coronavirus Infec-tion Covid-19 Sars-cov-2

Authors:
Stanislav Kostenko, Andrey Zemskov, Vladimir Zemskov, Maria Kozlova, Nadezhda Shishkina, Valentina Demidova, Sergey Suchkov, Konstantin Pronko, Oleg Vasiliev, IrinaTulinova, Tatiana Muha, Russia

Abstract:

Patients with moderate Covid-19 severity were divided into three groups - with a complete absence of IL-6 in the circulation, with a low and rather high (17.75 - 99.5 pg / ml) content of IL-6. It was revealed that at the lowest concentration of IL-6, patients had a mild variant of the moderate course of Covid-19 and recorded minimal levels of leukocytes, neutrophils, lymphocytes, monocytes, total T-lymphocytes and T-helpers, B- lymphocytes, immune indices “neutrophils/ lymphocytes”, CD4+/CD8+. However, with greater severity of the course of Covid-19 of moderate severity and a high content of IL-6, all these indicators significantly increased except for natural killer-effectors, the changes of which were of an opposite nature. It is suggested that a sufficiently high level of IL-6 in the case of moderately severe Covid-19 may be necessary to implement a balanced immune response, in contrast to a milder course, which in this sense may be insufficient. It can be assumed that the level of IL-6 can to a certain extent predict the severity of Covid-19.

DOI: http://dx.doi.org/10.51505/ijmshr.2022.6401