Title:
Different Pathophysiological Mechanisms of Irritable Bowel Syndrome

Authors:
Mehmet ÜNAL, Turkey

Abstract:

Introduction: Irritable bowel syndrome (IBS), which is the most frequently diagnosed gastrointestinal condition, is a symptom-based condition defined by the presence of abdominal pain or syndrome accompanying altered bowel habits, in the absence of another disease that may cause such symptoms. The pathphysiology of IBS is unknown, however, the prevailing hypothesis relates to gut-brain interaction disorder which occurs due to various relevant factors, alone or in combination. These factors include visceral hypersensitivity, abnormal gastrointestinal motor function, altered gastrointestinal mucosal and immune function, abnormalities in the gut microenvironment and alterations in the functioning of the central nervous system.

Method: The present paper is a review study focusing on different pathphysiological mechanisms that may cause IBS.

Results: As a result of the examination, we observed that ileocecal valve dysfunction, abdomino-phrenic dyssynergia, gastro paresis, pancreatic exocrine insufficiency, biliary dyskinesia and gut-brain axis play a role in the path physiology of IBS. Some of those contribute the direct development of IBS, whereas some others worsen IBS symptoms.

Conclusion: There exist different pathphysiological mechanisms that play a role in the development of IBS. Having knowledge about these mechanisms may provide insight into future clinical studies to be conducted. In addition making right interventions to these mechanisms can prominently reduce the economic burden of IBS on states. 

DOI: http://dx.doi.org/10.51505/ijmshr.2022.6603