Title:
Taxotere-Related Sclerodermia

Authors:
Vincent W. Lokonga K., L. Amaadour, M. Yessoufou, V.Litique, K. Oualla. Z. Benbrahim. S. Arifi, N. Mellas, Morocco

Abstract:

Introduction

The taxotere is an antineoplastic more used in cancerology in several gyneco-mammary, urological, digestive locations with acceptable and manageable toxicities. However, there are rare toxicities such as scleroderma which should not be neglected and taken into account as it is increasingly encountered.

Observation

A 78-year-old patient with a history of operated squamous cell carcinoma of the thigh, who presents with metastatic prostate cancer, treated with first-line taxotere who presents a rare complication: scleroderma confirmed on imaging, treated with corticosteroid therapy and drug cessation with good clinical outcome.

Conclusion

Scleroderma is a rare complication which should not be ignored in patients on taxoteric. This complication is related to the cumulative dose, discontinuation of treatment and corticosteroids constitute effective management.

DOI: http://dx.doi.org/10.51505/ijmshr.2023.7501