Title:
Effect of Ethanolic Extract of Datura Stramonium on Muscle Relaxant Activity by Docking Study of Gallic Acid and Gabba a Receptor and Rotarod Method in Mice

Authors:
Dr. B. Rambabu*, India

Abstract:

Background: The current study examined Datura stramonium leaves' ability to relax muscles. The extract's ability to relax muscles was evaluated using a variety of animal models. The study's objective was to compare the skeletal muscle relaxant properties of diazepam with the aqueous extract of Datura stramonium leaves in albino mice.

Materials and Methods: Twenty Swiss albino mice, of either sex, weighing between 100 and 150 g, and aged 5 to 6 weeks were used. Two distinct dosages were chosen following acute toxicity tests. They separated the animals into four groups. Different dosages of the EEDS were administered to the first group, which was retained as the control (normal saline), the second as the standard (diazepam), and the remaining two as Test I and Test II.

Results: At a maximal effect of 20 mg/kg i.p., the EEDS demonstrated substantial action. The EEDS (100, 250, 500, and 1,000 mg/kg) and EEDS (200, and 400 mg/kg) were deemed safe in the acute toxicity screening test. Rotarod activity is conducted with skeletal muscle relaxant action (motor coordination). Analysis of variance and Dunnett's multiple comparison tests were used for statistical analysis.

Conclusions: According to our research, EEDS has skeletal muscle relaxant properties.

DOI: http://dx.doi.org/10.51505/ijmshr.2025.9509