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Abstract: Stevia rebaudiana, a natural sweetener has long been utilized to promote liver function. The antioxidant and liver-protective properties of stevia were examined in this study in relation to rats' liver damage caused by carbon tetrachloride. To explore the phytochemical analysis of Stevia and to evaluate the hepatoprotective effect of Stevia in CCl4 induced hepatic injury rat model. The study was an experimental investigation carried out at the Food Analysis Laboratory, with the experimental procedures carried out in the rat facility at the Faculty of Allied Health Sciences, Riphah International University, Lahore Campus. In albino rats, the effects of Stevia, a non-calorific sweetener, on liver damage caused by carbon tetrachloride (CCl4) were assessed. Hepatotoxicity was induced by i.p administration of 30% CCL4 suspended in olive oil (1ml/kg Body weight). Animals were sacrificed at the end of the treatment period, and tests of antioxidant activity (FRAP, DPPH, TPC, and TFC) and biochemical markers (Lipid Profile, RFTs, LFTs, and Serum Glucose) were performed. Data analysis was done using MS-Excel and SPSS'25. The study examined four groups: the Normal, Diseased, Standard Drug, and Treatment group. The group that received Stevia treatment had notable hepatoprotective and antioxidant benefits. The phytochemicals found in Stevia, which are rich in antioxidants, lowered blood creatinine levels, stabilized protein and bilirubin levels, balanced liver enzyme levels (ALT, AST, and ALP), and greatly maintained liver function. Additionally, body weight, water and feed consumption, and other general health parameters were maintained by stevia. The findings suggested that Stevia may be able to prevent CCl4-induced liver damage if taken beforehand, and this effect is linked to Stevia's hepatoprotective properties.DOI: http://dx.doi.org/10.51505/ijmshr.2025.9604 |
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