Title:
Microvascular Dysfunction in Chronic and Recurrent Perianal Diseases: Clinical Correlations and Therapeutic Implications

Authors:
Aliaa A. Abdulqadir Aldhahi, Iraq

Abstract:

Perianal pathologies affect a substantial portion of the population and significantly reduce quality of life. These conditions have a complex physiopathology in which microvascular dysfunction plays a fundamental role. Accumulating evidence shows that endothelial alterations and microcirculatory failure are central to fissure, ulcer, abscess, and fistula formation. Therapies that improve endothelial function and microvascular perfusion demonstrate enhanced healing rates. Nutritional optimization, smoking cessation, and vasoprotective drugs further support these outcomes. However, well-designed clinical trials are still needed to confirm causal associations and establish targeted microvascular interventions for chronic and recurrent perianal diseases.

DOI: http://dx.doi.org/10.51505/ijmshr.2025.9608