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Authors:
Jihane Belkhair, Bouflioua El Ghali, Allali Asma, Mouamin maryam, Mohamed Chakour, Morocco
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Abstract:
Background: The diagnosis of leukemia is biological by morphological examination of peripheral blood films, the Bone marrow study, and cytochemical staining, and advanced diagnostic procedures like immunophenotyping, cytogenetic analysis, and molecular genetics for unclassified case.
Methods: The study was conducted in Avicenna Hospital in Marrakech from june 2010 to June 2016. Consecutive patients diagnosed with acute leukemia were included in the study. Details were collected as regarding demographic factors, symptoms, signs, laboratory parameters. The morphological typing and sub-typing of leukemia was based on peripheral smear examination, bone marrow studies (aspiration and biopsy) employing the FAB criteria, and immunophenotyping.
Results: In our study of 60 patients with acute leukemia, 37 cases had AML, 16 cases had ALL and 7 cases remained as unclassified acute leukemia. Pallor is the most common physical sign in 74%. Anemia is the most common hematological abnormality in 90%. In peripheral, 61,6% were ALM against 26,6% were ALL and 11,7% remained unclassified after bone marrow.
Conclusion: A complete blood count with a careful reading of blood and marrow smears supplemented by cytochemical reactions still allows the classification of most acute leukemia.
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