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IJMSHR

Title:
Evaluation of the Appropriate Use of Carbapenems Regarding Patients Taken in Hand by Intensive Care Unit in the Marrakech University Hospital Center

Authors:
Mouayche Ikhlas, Abdesalam Hiddou, Hanaa Hamdani, Youssef Louardi, CharafHarda, Amra Ziadi, Amina Khayari, Abdelhamid Hachimi, Youssef Mouaffak, Said Younous, Nadia El Idrissi Slitine, Mrabih Rabou Maoulainine, Nabila Soraa, Morocco

Abstract:
Introduction:
Carbapenems are antibiotics of last resort used to treat infections with multi-resistant bacteria. The objective of this study is to analyze the prescriptions of carbapenems (CBP) and evaluate the conformity of the probabilistic prescription of these molecules.
Materials and methods:
This is a prospective study over from 1 August 2016 to 31 December 2016.
Results:
100 prescriptions of an antibiotic of the carbapenem class were collected. Percentage of prescriptions for CBP was highest in neonatal intensive care (36%) and adult intensive care (34%). The main indication for prescribing CBP to the different intensive care services was sepsis and septic shock (45%). This prescription was probabilistic in 67% of cases. Nosocomial infection motivated the prescription of CBP in 76% of cases. 27 percent of CBP prescriptions were made to treat a documented infection to a C3G-resistant by production of ESBL. Imipenem was predominantly prescribed in neonatal intensive care unit and adult surgical intensive care unit. Erapenem was prescribed in 28% of Cases in medical intensive care unit and 20% in pediatric intensive care unit. Imipenem was prescribed in accordance with the standards in 88% of cases, ertapenem in 10% of prescriptions and meropenem in 2% of prescriptions. Doses were compliant for 87 prescriptions.
Conclusion:
The conformity rate has yet to be re-evaluated and improved. The appointment of a referent in antibiotics is essential to supervise the prescription of these broad spectrum antibiotics and limit their use.

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