There are many side effects known from post-mastectomy. Most disabling are pain and restricted range of motion of shoulder joint due to post Cancer Mastectomy induced lymphadenopathy. Limited arm or shoulder movement further affects an individual's functional and social well-being. With the aim to reduce the lymphedema either we lose range and strength or vice versa. Hence the aim of the present study was to evaluate the effectiveness of the novel physiotherapy protocol for the post-mastectomy and radiotherapy-induced lymphadenopathy and restricted range of motion. A 62 years old female was included in the study. Baseline data were recorded by visual analog scale, forearm girth measurements and Hospital Anxiety and Depression (HAD) scale. Results were then noted at 1st, 2nd, 3rd, 4th, 5th and 6th month of the study. Studies proved Matrix Rhythm Therapy to be beneficial in reducing lymphedema, pain incising functional and social well-being when combined with other conventional.