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Antisperm Antibody is not Associated with Infertile Males with Epididymal Cyst

Huan Jiang, Bao-Guo Xie and Wei-Jie Zhu, China

Objective: The purpose of this study was to investigate the level of antisperm antibodies (ASA) in infertile men with epididymal cyst (EC). Materials and Methods: A total of 42 infertile men with unilateral EC diagnosed by scrotal color Doppler ultrasonography were enrolled in the study. Semen samples were analyzed and ASA levels were measured by direct immunobead test for ASA types IgG and IgA according to the World Health Organization (WHO) laboratory manual (2010). Leukocyte was determined using a myeloperoxidase staining method. Results: Of these 42 infertile men with EC assessed for ASA-IgG, only two cases (4.8%) were respectively present 12% and 18% motile spermatozoa binding to immunobeads in sperm samples. None of these cases satisfied the clinical positive level for ASA-mediated infertility according to the WHO criteria, whilst relatively abnormal sperm parameters were revealed in partial cases. ASA-IgA was not detected in all cases. Nine (21.4%) cases with EC showed that leukocytes were increased in their samples. Conclusions: The significant incidence of ASA was not found in infertile men with EC, which suggests that EC would have not an increased risk for the production of ASA. But increased leukocytes in semen of the cases would be noted for their treatment

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