According to UNICEF there are 220,000 adolescents infected by HIV/AIDS in India. In which around 70,000 adolescents are below the age of 15 and 21,000 adolescents are being infected through mother-child transmission every year. "A quasi experimental study to evaluate the effectiveness of 'Holistic Humanized Nursing Care strategy' on physiological parameter of adolescents living with HIV in selected settings". Quantitative research approach was adopted, quasi experimental research which includes control group and manipulation with no randomization. The settings of the study were Integrated Child Welfare Organization (ICWO), Thiruvallur. The sample consist of 40 adolescents in experimental and control group who were diagnosed to have HIV and met inclusion criteria and chosen by non probability purposive sampling technique. The tool used was a demographic variables to find the association between HRQOL gain score and fatigue reduction score related to demographic variables in experimental and control group results found are male adolescents, urban adolescents, healthy mother status adolescents, healthy father status of adolescents and healthy sibling status of adolescents are gained score at the level of p<0.05 than others. Statistical significance was calculated using Mann-Whitney U-test and kruskal-wallistest. The demographic variables are highly significant.