Introduction: Prolonged IRS promised to induced renal dysfunction, yet, only a small part of affected individuals seek medical attention. Several studies have described complementary and alternative medicine as effective strategies for improving renal function through safety root such as fermented food. The purpose of this study was to provoke the effect of a fermented herbal derivative (FHD) to renal function. Methods: In this approach of alternative study, participants with prolonged IRS lasting 6 months were randomly allocated into two groups: a fermented derivatives group and a control group. The group consumed fermented herbal derivatives consisting of 80 sorts of herbs and fruits twice daily for three weeks, whereas the control group did not. The primary result was IRS severity as measured FHD by digital scale. Secondary outcomes included sleep quality, dysfunction symptoms, and quality of life as measured FHD, Beck Dysfunction Inventory, respectively.
Results: Of 12 individuals screened, 10 completed the study. The mean change the renal dysfunction in IRS severity was significantly larger in the control group than in the experimental group at 0 day and improvements in IRS severity were recovered at 30,60,90 and 120 days follow-up. Biochemical quality of renal function was also promoted in the experimental group at 30 days after to 120 days. Moreover, CD positive cell as parameter of immune function also improved in quantitatively and qualitatively during the experimental period.
Conclusion: The present results suggest that the fermented herbal derivative formulation reduces renal dysfunction in human and improves CD positive lymphocyte functions in patients with prolonged renal IRS.