Objective: In the present study, we aimed to investigate vitamin D levels among Familial Mediterranean Fever (FMF) patients both during attacks and attack-free periods and evaluate its association with attacks.
Material and Method: Twenty patients in the attack and twenty patients in the attack-free period were enrolled in the study. 25 hydroxyvitamin D levels were quantified using a high performance liquid chromatography (HPLC) method. Patients were questioned for their complaints during an attack, medications they were using, the frequency of attacks, their family history and duration of disease.
Results: %72,5 of all patients had 25 hydroxyvitamin D deficiency.25 hydroxyvitamin D level (mean +- SD) was 17.9 +- 7.8 ng/ml for patients in the attack period and 14.1 +- 7.13ng/ml for patients in the attack-free period. There was no statistically significant difference between the 2 groups in vitamin D levels (p=0,1). We did not find a significant association between attack frequency and vitamin Dlevels. (r=0,27 p=0.09). However there was a statistically significiant difference between genders in vitamin D levels and attack frequency. (p=0.04; p=0.01)
Conclusions: In this study there was no significant association between attack frequency and vitamin D levels, however there was a significantly difference in attack frequency between genders. Future studies with a larger number of patients would be beneficial in evaluating the relationship between vitamin D levels, genders and attack frequency in FMF patients.