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Effect of Process Methods on the Preventive Effects of Asymmetric Curcumin Analogues as Hepatoprotectors in Male Mice (Mus Musculus L.) Induced by CCl4

Imanuel Berly Delvis Kapelle*, Wasmen Manalu, Shielda Natalia Joris, Indonesia

One of the synthetic products obtained from culilawan oil with a very active dioxolane ring is asymmetric curcumin analogue compound (AKAS). AKAS products can be synthesized use conventional methods and the microwave method. The synthesis process method can influence physical properties and geometry of compounds as well as pharmacological effects. The purpose of this study was to determine the effect of the process method on the preventive effect of asymmetric curcumin analogues as hepatoprotectors in male mice (Musmusculus L.) induced by CCl4 and to know the effective dose as hepatoprotector. The method used is in vivo using mice and as a comparison ingredient of turmeric extract (curcumin) and Heap Q. The parameters observed are the SGOT and SGPT values and histopathological analysis using the H&E method. The results showed that the method for the synthesis process of asymmetric curcumin analog products from culilawan oil had an effect on the hepatoprotector effect. Products synthesized using the microwave method (AKAS-m) give better results when compared to conventional methods (AKAS-k) and the effective dose as a hepatorotector is AKAS-m dose 26 mg / 200g bw.

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