Title:
Analysis of Relationship of Hypertension with Metabolic Syndrome and Rs1137101 LepR Gene Polymorphism in Mexican Treated Hypertensive Subjects

Authors:
Elva Perez-Luque, Mónica I. Cardona Alvarado, Nicté Figueroa-Vega., Mexico

Abstract:

Insulin resistance and hypertension are closely related with metabolic syndrome (MS). To explore the relationship between hypertension with metabolic syndrome and rs1137101 LepR polymorphism in Mexican hypertensive patients treated. We recruited two groups of both genders aged 30 to 50 years: 1) Normotensive subjects without antecedents of metabolic or chronic diseases; and 2) treated hypertensive patients. The anthropometric measurements were measured, adiposity distribution indices were calculated and blood pressure was taken. The fasting serum glucose, lipid, insulin and leptin levels were quantified, and rs1137101 was genotyped. We selected 248 normotensive subjects and 173 treat hypertensive patients, 227 women and 194 men. In subjects with metabolic syndrome (MS) 67.9% were hypertensive, and 51.1% of hypertensive patients had MS. The waist-height index was significantly higher in MS subjects than in hypertensive patients. The analysis by genotype in the entire group showed that carriers of the AA and AG rs1137101 genotypes had higher systolic and diastolic pressure, and higher leptin levels in hypertensive patients with the GG genotype. The waist-height index could help distinguish only treated hypertensive patients from those with metabolic syndrome. The rs1137101 polymorphism is related with blood pressure and leptin levels.

DOI: http://dx.doi.org/10.51505/ijmshr.2025.9212